Core Decompression Combined with Intraosseous Autologous Conditioned Plasma Injections Decreases Pain and Improves Function in Patients with Symptomatic Knee Bone Marrow Lesions

The purpose of this prospective case series was to determine the effectiveness using a combination core decompression and injection autologous conditioned plasma (ACP) for treatment symptomatic knee bone marrow lesions (BML), as well report on preliminary clinical results based magnetic resonance imaging (MRI) patient-reported outcomes (PROMs). Patients with OA-related BML who failed improve conservative three months underwent an identical procedure consisting arthroscopy, decompression, intraosseous ACP were followed up 12 months. A statistically significant reduction in pain improvement function, measured by Numeric Pain Rating Scale (NPRS) Knee Injury Osteoarthritis Outcome Score (KOOS), observed at one-week follow-up (8.3 ± 0.8 1.5 1.0; p ≤ 0.001 33.4 10.6 53.9 13.6; respectively). After six weeks, weight-bearing allowed, but trend did not change—the NPRS continued be low (average 1.4 12-month follow-up) total KOOS increased 44.6 points from baseline 78.0 follow-up). Whole-Organ Magnetic Resonance Imaging improved 66.1 19.4 prior surgery 58.0 15.9 (p < 0.001) after 3 In our study, there no control group, randomisation performed, sample size relatively small. into affected subchondral area proved safe effective that provides rapid relief increase joint function one year postoperatively.